· Those in Kuala Lumpur, Malaysia for a month or more.
· Those who are carriers or have a family history of a genetic disorder.
· Those who have a child/children affected with a genetic disorder and want to have another baby.
· Those who want to reduce the chance that their baby will be affected by an inherited genetic disorder.
What is Karyomapping?
Karyomapping is a method that can help to reduce the chances of couples - known or tested to be carriers of an inherited condition - from passing on the disorder to their baby. If you know that you are a carrier, have a family history of a disorder or already have an affected child, this treatment can help to avoid passing the gene to your baby.
Karyomapping works by screening embryos before implantation in the womb. This is called preimplantation genetic diagnosis or PGD for short.
To carry out PGD, in vitro fertilisation (IVF) is essential. IVF involves collecting several eggs and fertilising them outside the body (in vitro) in order to produce several embryos. These embryos will then be tested to pick the healthiest one. Embryos that are predicted to be free of the disorder are transferred to the uterus, hence reducing the risk of the baby getting the genetic disorder.
How It Works
A blood sample will be taken from the father, mother and one or more relatives who are affected by / carriers of the disorder. The closest relative may be the couple’s affected child.
Karyomapping will examine the chromosomes and the reference at 300,000 different points, looking for features of the defective chromosome.
It then uses the DNA fingerprint of the defective chromosome during the testing of embryos produced by IVF to look for the affected embryo.
If this identification is not detected in an embryo, then it can be inferred that the embryo is predicted to be free of the disorder.
· DNA sample of the couple and at least 1 more relative who carries the defective gene
· A sample may be needed from relatives on each side of the family if the disorder is recessive
· If only 1 side of the family carries a defective gene, additional samples are needed from that side of the family only.
· In some cases, a sample from a non-carrier relative may also be needed to compare the DNA fingerprint associated with the defective gene.
Advantages and Limitations of Karyomapping
· Safe procedure
· Enables the transfer of healthy embryos
· Reduces the chances of passing on a defective gene for genetically at-risk couples
· Lowers the risk of miscarriage due to structural chromosomal abnormalities
· Karyomapping is a technique to reduce the risks of passing on the defective gene. It is not an absolute guarantee.
Q1: How accurate is karyomapping?
A1: The chance of karyomapping to detect an affected embryo successfully is better than 95%. It tests a single cell or sometimes a small number of cells taken from the embryo. Tests involving that tiny amount of tissue can never be 100% accurate.
Q2: Does it detect any other abnormal genes?
A2: No, it will not detect other rare genetic conditions other than the particular condition affecting your family. If you have any concerns regarding other genetic conditions, please consult with the doctor to know other possible tests you can take.
Q3: Will I have a healthy pregnancy?
A3: Karyomapping can significantly increase the chances of a healthy pregnancy since healthiest embryos can be selected.
Q4: Are the DNA samples necessary?
A4: Yes. In all cases, official genetic test reports are required before performing the test, which uses the DNA reports as a reference.
[Clinic Name] Sunfert International Fertility Centre @ Bangsar South
[Location] Kuala Lumpur, Malaysia
[Nearest Stations / Attractions] Located in the city center, 15 mins drive from KLCC and easily accessible via the LRT (Light Rail Transit) from many entertainment and shopping districts in the city, and is surrounded by service apartments, hotels, and a variety of F&B outlets.
[Clinic Opening Time] Monday, Wednesday and Friday (7:30AM - 5:00PM); Tuesday, Thursday and Saturday (7:30AM - 4:00PM); Closed on Sunday and Public Holidays
Number of Postoperative Visit
Suitable for women with AMH > 14pmol/l
Once booking is confirmed, you may be charged a penalty fee upon booking cancellation