Stem Cell Culture Supernatant (Cytokine Therapy)

· Those in Tokyo interested in cytokine therapy.
· Those with aging skin.
· Those with damaged skin tissues.
· Those who wish to have youthful skin.
· Those who wish to have better skin appearance.

Stem cells are the body's most important raw materials, from which all other cells with specialized functions are generated. Within the body/laboratory, under the right conditions met, stem cells divide and form more cells, called daughter cells. The daughter cells then are divided into two paths: new stem cells/specialized cells. The new stem cells play the role in self-renewal while specialized cells are naturally responsible for more specific functions, such as to generate blood cells, brain cells, heart muscle cells, nerve cells, and bone cells, etc.

Stem cells detect the weakened parts of the body and regenerate them swiftly.
With the ability to build every tissue in the human body, stem cells have excellent potential in repairing as well as regenerating new tissues. This then allows various studies to be further conducted for future therapeutic uses, which at present it is existing and known as "regenerative medicine".

Cytokines are small proteins that are crucial in controlling the growth and activity of various immune system cells as well as blood cells. They are responsible for acting as signals to boost the immune system into function. Cytokines have a significant impact on all blood cells and other cells that help the body's immune and inflammation responses. They also help to boost anti-cancer activity by sending signals that can help make abnormal cells die and normal cells live longer.

Cytokine therapy is an innovative treatment with the main aim of regenerating skin for aging and damaged skin tissues. The procedure is considered as a cell-free regenerative medicine as no stem cells are used directly for the treatment, but the materials present within the stem cell culture fluid (supernatant) is utilized instead.

At our affiliated clinic, there are two choices of supernatant available for the preference depending on the skin condition.

Adipose tissue-derived stem cells (ADSCs) are mesenchymal cells with a strong capacity for self-renewal and multipotential differentiation. With this, they can produce various cells such as adipocytes, chondrocytes, myocytes, osteoblasts, and neurocytes. They play key roles in tissue reconstruction for better skin function and appearance.

Human embryonic stem cells (ES Cells) are derived from the inner layer of the blastocyst, also have an essential effect on tissue engineering and regeneration.

Although both types of stem cells have similar functions, Adipose tissue-derived stem cells are known to have better regenerative medicine as they are considered to provide more tissue protection, antiapoptosis, and cell replacement. In addition, they are easily accessible as the tissues can be conveniently harvested by plastic surgery procedure and they are ideal kind of adult stem cells.

1. Initial consultation and examination
2. Schedule of the treatment plan, depending on the condition
3. Injection of autologous fat-derived stem cells/embryonic stem cells
4. Follow-ups scheduled

Stem cell therapy has been reviewed by the Specified Certified Regenerative Medicine Committee approved by the Ministry of Health, Labor and Welfare for its adequacy, safety, physician system, and cell processing management system. In order to perform the treatment, a provision plan has to be submitted.
Our affiliated clinic has submitted a provision plan to the Ministry of Health, Labor and Welfare and has successfully deemed appropriated and obtained a license and patented to proceed with the treatment.

<Advantages>
· Reverses aging skin
· Improves skin tone and texture
· Enhances better skin condition
· Revives youthful skin

<Limitations>
· May require a few therapy sessions
· Therapy takes some time to be effective
· Fever, redness, rash may occur temporarily up to 24 hours after the treatment

Q1: Does the treatment hurt?
A1: Merely some discomfort may be experienced during the procedure.

Q2: Is there any side effect?
A2: There may be minor internal bleeding or inflammatory but the procedure is absent with major risks.

Q3: How long will it take for stem cell therapy to make a difference?
A3: Most patients notice the improvement after 3 weeks and it is possible for some patients to start noticing after 6 to 8 weeks as well. Despite the period, once the improvement is experienced, a continuous process will be noticeable for at least 6 months.

[Clinic Name] La Grand Clinic
[Location] Tokyo, Japan
[Nearest Station/ Nearest Tourist Destination] Clinic is located in Ginza, near Pola Museum Annex Art Gallery and strategically located among eateries and shopping malls.
[Clinic Opening Time] Tuesday - Friday (12:00PM - 8:00PM ; closed 3:00PM - 4:00PM) ; Saturday (10:00AM - 6:00PM ; closed 1:00PM - 2:00PM) ; Clinic Closed on Monday and Public Holiday